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M9490130.TXT
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1994-09-03
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Document 0130
DOCN M9490130
TI Comparative study on some systemic humoral and cellular immune markers
in only HIV or HIV and hepatitis B infected children.
DT 9411
AU Voiculescu C; Balasoiu M; Turculeanu A; Filipas L; Voiculescu M;
Georgescu D; Faculty of Medicine Craiova, Department of Microbiology
and; Immunology, Romania.
SO Rev Roum Virol. 1993 Jan-Jun;44(1-2):97-111. Unique Identifier :
AIDSLINE MED/94318524
AB Three different groups of asymptomatic children, aged from 12 to 24
months (30 subjects per each group), i.e. controls, only HIV, or
HIV/hepatitis B virus (HBV) double infected, were studied, as concerned
the following systemic immune parameters: immunoglobulin (IgG, IgM, IgA,
IgD) levels; absolute numbers of blood CD+4, CD+8, CD+16 and CD+19
cells; phytohaemagglutinin (PHA)-blast responsiveness of T lymphocytes;
natural killer (NK) cell activity--as tested by means of cytotoxicity
assays; per cent suppression of PHA-dependent T cell blastogenesis in
the presence of concanavalin A (Con A) selected T suppressor (Ts) cells.
On the other hand, in 15 ARC-shifting cases belonging to HIV, and
HIV/HBV groups, respectively, a second serum sample was collected and
searched comparatively with the corresponding first serum sample, as
regarded: presence of total and anti-p24 HIV antibodies, patterns of
Western Blot (WB), as well as amounts of free p24-HIV antigen. In
asymptomatic double HIV/HBV infected subjects, some immune disorders
occurred, at a more significant degree, as compared to only
HIV-infected. Once the shift toward ARC being installed, in both
infected groups a decrease of anti-p24 HIV antibody presence,
disappearance of corresponding band in WB confirmation test, as well as
presence of free p24 antigen in serum, were noticed. However, greater
amounts of p24 antigen in HIV/HBV infected, as compared to only HIV
infected patients, were found. Some considerations about diagnostic and
predictive value of presented data are discussed.
DE Antibody Formation Antigens, CD/BLOOD AIDS-Related Complex/IMMUNOLOGY
Biological Markers/BLOOD Child, Preschool Comparative Study Hepatitis
B/*IMMUNOLOGY Hepatitis B Surface Antigens/BLOOD Human HIV
Antibodies/BLOOD HIV Infections/*IMMUNOLOGY *HIV-1/IMMUNOLOGY
Immunity, Cellular Immunoglobulins/BLOOD Infant Killer Cells,
Natural/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).